Endocrine Abstracts

Background and aims: Type 1 diabetes (T1D) is a chronic autoimmune disease, characterized by T-cell mediated destruction of the pancreatic insulin-producing beta-cells. Neutrophils, cells of the innate immune system, have been shown to infiltrate the pancreas and undergo neutrophil extracellular trap (NET) formation (NETosis). However, little is known about the involvement of neutrophils and specifically the role of NETosis in the pathophysiology of the disease. Our aim was to...

Background and aims: Combining systemic immunomodulation with disease-relevant antigens could provide longer-term solutions for preventing and even reversing autoimmune type 1 diabetes (T1D). Our team established that a combination therapy (CT), composed of a short-course low-dose anti-CD3 treatment with oral delivery of genetically-modified Lactococcus lactis (L. lactis) bacteria secreting full proinsulin plus the anti- inflammatory cytokine IL-10 (LL-PINS+I...

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Aims/hypothesis: The initial avascular period following islet transplantation seriously compromises graft function and survival. Enhancing graft revascularization to improve engraftment has been attempted through virus-based delivery of angiogenic triggers, but risks associated with viral vectors have hampered clinical translation. In vitro transcribed mRNA transfection circumvents these risks and may be used for improving islet engraftment.Meth...